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. 2017 Nov 17;8:1594. doi: 10.1038/s41467-017-01482-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Increased contractility in the ectoderm is sufficient for furrow unfolding. a, b Snapshots from a Tom>RhoV14 embryo movie (ventral view; Gap43-Cherry, white, and tracking, red). This embryo also expressed MyoII-GFP. While ventral furrow formation (a) and collective apical constriction (b; wild-type control, red) occurred normally, furrow unfolding was observed soon afterwards. c Mean MyoII intensity values measured in tracked ventral cells of wild-type (green), Brd (brown), and Tom>RhoV14 (purple) embryos were plotted over time. Black stamps indicate the onset of furrow unfolding (mean values; see Supplementary Fig. 9e for the complete data set). d–f Snapshots from movies wild-type (d), Brd mutant (e), and Tom>RhoV14 (f) embryos expressing MyoII-GFP (white) and Gap43-Cherry (tracking, red). Ventral–lateral views are shown. MyoII-GFP intensity was measured in ventral ectodermal cells (yellow-shaded in d–f) of wild-type (n = 3), Brd mutant (n = 3), and Tom>RhoV14 (n = 3) embryos