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. 2017 Nov 13;8:911. doi: 10.3389/fphys.2017.00911

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Copyright © 2017 Song, Wang, Li, Chen, Liu, Chen, Li, Li, Li, Lian and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTHrP does not affect proliferation of Leydig cells in vivo. Immunofluorescent staining of PCNA (red color in the nucleus) and 11β-HSD1 (green color in the cytosol) of the testes from the rats treated with 0 (A), 10 (B), and 100 (C) ng/testis PTHrP on post-EDS day 7 for 21 days. (D): Quantitative data. White arrow indicates PCNA-positive Leydig cells. White “^*” indicates PCNA-negative Leydig cells. Mean ± SEM, n = 6. No significant difference between PTHrP group and the control was observed.