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. 2017 Nov 17;7:15756. doi: 10.1038/s41598-017-15943-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in ductular reaction, hepatic stellate cells/myofibroblasts and macrophage pool between biopsies obtained from patients carrying or non carrying non-synonymous variant I148M in human patatin-like phospholipase domain containing 3 gene (PNPLA3). (A) Immunohistochemistry for Cytokeratin 7 (K7). Patients with PNPLA3 variant were characterized by a more extended ductular reaction if compared with WT patients. Original Magnification (OM) = 20x. (B) Immunohistochemistry for α smooth muscle actin (αSMA). Higher number of portal/periportal αSMA-positive myofibroblasts was revealed in patients with PNPLA3 variant when compared with WT patients. OM = 10x. (C) Immunohistochemistry for S100A9. Patients with PNPLA3 variant were characterized by a higher number of S100A9-positive macrophages within the portal spaces (arrows) in comparison with WT patients. OM = 20x.

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