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Effect of cebranopadol on place-conditioning test. Neither of the two doses of cebranopadol induced place conditioning, although a trend to spend more time in the drug-paired compartment could be observed. Inset: morphine induced a clear place preference. Morphine’s preference score was 1.7-fold higher than cebranopadol’s. Preference score is reported in seconds. Data are presented as mean ± SEM. *p < 0.05 vs. control group.
