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. 2017 Nov 17;8:1603. doi: 10.1038/s41467-017-01624-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Brevican in MG of disorganized human retinitis pigmentosa retinas. a–m Immunofluorescence for Tomato, GFAP, and Sox2 (a–c) or glutamine synthetase (GS) and Brevican (d–m), as well as DAPI nuclear staining of retinal cross sections of retinitis pigmentosa patients. Glial aggregations (white arrows in b, c) found in the INL resemble to those found in the 6-month-old Dicer-CKO_MG retinas. MG in intact regions (arrows in g, h) were Brevican^– while glial aggregations found in disturbed regions (arrows in l, m) were Brevican⁺. n Brevican/GS immunoreactivity assessed in intact (n = 4) and disturbed (n = 8) retinitis pigmentosa samples showed a significant increase in Brevican protein level in the disturbed samples. Statistics: mean ± S.E.M., independent samples t-test and Levene’s test for equality of variances, 2-tailed, p = 0.0323. Scale bars in a, i: 100 μm, in b, d: 50 μm in g, l: 25 μm. ONL, OPL, INL, IPL, GCL, NFL as defined in Fig. 1 legend, RP retinitis pigmentosa