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. 2017 Jul 22;12(4):682–692. doi: 10.1007/s11481-017-9755-4

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — TDF/FTC/RAL combined medication affects mouse NPCs in a dose- and time-dependent manner. Viability of cultured mouse NPCs was determined using the CCK-8. a Mouse NPCs were treated with increasing concentrations of TDF/FTC/RAL (0.1×, 0.3×, 0.5×, and 1×), and cell viability was measured on day 8. b Mouse NPCs were treated with 0.1× TDF/FTC/RAL and cell viability was determined on day 2, 4, 6, and 8. Control groups were treated with DMSO. Ara-C (7 μg/ml) served as a positive control. *** denotes p < 0.001, **** denotes p < 0.0001 compared with control