Table 2.
EGCG decreases or increases the expression of stemness marker mRNAs and proteins by human CSCs
| Cancers and names of CSCs | Inhibited expression of stemness markers (mRNAs and proteins) | References |
|---|---|---|
| Breast CSCs | ||
| SUM-149 & SUM-190 | mRNAs: CCND1, RHOC, BCL-XL | Mineva et al. (2013) |
| SUM-149 | mRNAs: FN1, CDHI, vimentin | |
| MDA-MB-231 & MDA-MB-436 | Proteins: ER-α36, EGFR, p-ERK1/2, p-AKT | Pan et al. (2016) |
| Lung CSCs | ||
| A549 & H1299 | mRNAs: CD133, CD44, ALDH1A1, Nanog, Oct4 | Zhu et al. (2017) |
| Proteins: CD133, CD44, ALDH1A1, Nanog, Oct4, PCNA, cyclin D1, Bcl2, p-GSK3β, β-catenin, c-Myc | ||
| Increased Bax, caspase 8, cleaved caspase-3 and -9 | ||
| Prostate CSCs | ||
| PC-3 & LNCaP | Proteins: XIAP, Bcl2, survivin, vimentin, Slug, Snail, β-catenin | Tang et al. (2010) |
| Colorectal CSCs | ||
| HCT116-5FUR & SW480-5FUR | mRNAs: Oct4, Nanog | Toden et al. (2016) |
| Proteins: Notch 1, cleaved-Notch 1, c-Myc, Bmi-1, Suz12, Ezh2 | ||
| HCT116-SDCSCs | mRNAs: CD133, Nanog, ABCC1, ABCG2 | Wubetu et al. (2016) |
| Proteins: Nek2, p-Akt | ||
| Liver CSCs | ||
| HepG2-SDCSCs | mRNAs: CD133, Nanog, ABCC1, ABCG2, | Wubetu et al. (2016) |
| Proteins: Nek2, p-Akt | ||
| Pancreatic CSCs | ||
| Pancreatic CSCs | mRNAs: Nanog, c-Myc, Oct4, Bcl2, survivin, XIAP, SMO, PTCH1, PTCH2, Gli1, Gli2, Snail, ZEB1, Slug | Tang et al. (2012) |
| MIA-PaCa2 & BxPc-3 | mRNA: K-ras (by green tea extract) | Appari et al. (2014) |
| Head and neck CSCs | ||
| HNSC (K3, K4, K5) | mRNAs: Oct4, Sox2, Nanog, Notch1, Hey1, Hes1 ABCC2, ABCG2 | Lee et al. (2013) |
| Proteins: Oct4, Sox2, Notch1, Hey1, Hes1, ABCC2, ABCG2 | ||
| Increased involucrin | ||
| Nasopharyngeal CSCs | ||
| TW01 & TW06 spheres | mRNAs: Oct4, KLf-4, vimentin, Snail
Increased E-cadherin |
Lin et al. (2012) |
| Glioma CSCs | ||
| U87 GSLCs | mRNAs: ABCB1, ABCG2, MGMT | Zhang et al. (2015) |
| Proteins: p-Akt, CD133, ALDH1, Bcl2, P-gp | ||
| Increased Bax, c-PARP | ||