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. 2017 Nov 17;7:15811. doi: 10.1038/s41598-017-16222-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) FTIR spectra of CS-ED-CD polymer and monomers. Spectra are labelled by chemical structure or compound name (top to bottom: chitosan, EDTA, β-CD, and amino-β-CD); (b) simultaneous conductometric-potentiometric titration curves of CS-ED-CD; (c) quantitative analysis of active β-CD cavities by photometric titration. Insert, bottom left: UV adsorption spectra of alkaline phenolphthalein solution treated with varying amount of pristine β-CD and 20 mg CS-ED-CD; top right: original alkaline phenolphthalein, treated with 20 mg CS-ED-CD, and treated with 12 mg pristine β-CD (from left to right).