Table 2.
Imaging features and pathologic results of 141 subsolid nodules according to IASLC/ATS/ERS International Multidisciplinary Classification based on SSN subclassfication.
| Pure GGN (N = 57) | Heterogeneous GGN (N = 22) | Part-solid nodule (N = 62) | P-value | P-value for Trend | |
|---|---|---|---|---|---|
| Lesion size | 9.081 ± 4.17 | 13.841 ± 5.98 | 19.145 ± 9.0818 | <0.0001**** | <0.0001 |
| Solid part | N/A | N/A | 9.435 ± 5.8991 | N/A | N/A |
| Air-bronchogram | 0 | 4 | 39 | <0.0001*** | N/A |
| Cyst-like airspace | 1 | 0 | 4 | 0.09*** | N/A |
| HU (mean) | −592.01 ± 113.55 | −435.27 ± 102.49 | N/A | <0.0001* | N/A |
| HU (max) | −526.87 ± 123.81 | −327.545 ± 125.56 | N/A | <0.0001* | N/A |
| HU (min) | −676.368 ± 129.069 | −578.59 ± 198.085 | N/A | 0.002* | N/A |
| IPA lesions | 4 (7.0%) | 8 (36.4%) | 53 (85.5%) | <0.0001**** | <0.0001 |
| Adenocarcinoma spectrum | <0.0001*** | N/A | |||
| AAH | 8 | 0 | 0 | ||
| AIS | 17 | 2 | 0 | ||
| MIA | 28 | 12 | 9 | ||
| IPA | 4 | 8 | 53 | ||
| Lung-RADS distribution | <0.0001*** | N/A | |||
| 1 | 0 | 0 | 0 | ||
| 2 | 55 | 21 | 0 | ||
| 3 | 2 | 1 | 5 | ||
| 4 | 0 | 0 | 57 |
*Using independent t-test for continuous variables; **Using Chi-square test for categorical variables; ***Using Fisher’s exact test for categorical variables. ****Using one-way ANOVA to compare three groups.
Abbreviations: AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; HU: Hounsfield unit; IPA: invasive pulmonary adenocarcinoma; MIA: minimally invasive adenocarcinoma; GGN: groundglass nodule; SSN = subsolid nodule. ANOVA: analysis of variance.