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. 2017 Nov 17;7:15795. doi: 10.1038/s41598-017-16101-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Risk of bias assessment of included trials. The methodological quality assessment was performed by using the Cochrane Collaboration’s tool to assess risk of bias in for included trials. Allocation sequence generation was adequate in most of published trials except open-label trials and the unpublished trials which were judged as unclear. Open-label trials were judged as high risk in the allocation concealment and blinding. Eleven trials were judged as unclear risk of incomplete data, because these studies did not address the outcome analysis. Selective report biases were not identified in the included studies.