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. 2017 Aug 9;9(13):1529–1538. doi: 10.4155/fmc-2017-0048

Figure 1. . Reverse transcriptase structure and sites of resistant mutations.

Figure 1. 

Locations of resistance-associated mutations mapped on the heterodimer of HIV reverse transcriptase in complex with NNRTI lersivirine (PDB: 2WOM). (A) Heterodimer of reverse transcriptase. The two subunits are shown as light gray and dark gray ribbons with NNRTI in black bonds. Sites of mutations associated with resistance to NRTIs are indicated by dark gray spheres on the left subunit. Mutations associated with NNRTI resistance are shown on the right in light gray [20]. (B) Expanded NNRTI binding site with mutations labeled. (C) Expanded region in left subunit with sites of mutations associated with NRTIs labeled.

NNRTI: Non-nucleoside RT inhibitor; NRTI: Nucleoside RT inhibitor; TAM: Thymidine analog-associated mutation.