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. 2017 Nov 13;8:1433. doi: 10.3389/fimmu.2017.01433

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Copyright © 2017 Kirik, Persson, Levander, Greiff and Ohlin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Substitutions of residues 84 (A), 85 (B), 90 (C), 92 (D), and 101 (E) in FR3 as introduced during somatic hypermutation processes of IgG-encoding genes derived from 11 different germline genes. Structure (F) of an IGHV5-51-derived scFv (PDB: 4BUH) indicating the side chain atoms of residues 84 (cyan), 85 (dark blue) in close proximity to CDR1, and of residues 90 (magenta), 92 (orange), and 101 (red). CDR are shown in brown (CDR1), green (CDR2), and light blue (CDR3).