Figure 5.

Extent of diversification of residues close to complementarity determining region (CDR) in the linear protein sequence as encoded by transcripts of different germline gene origins. Residues shown include residues 39, 40, 42 immediately after CDRH1, and residues 54–55 immediately before and residues 66–69 immediately after CDRH2 of IgG. Residue 41, a conserved tryptophane belonging to the domain’s core, is not diversified in products encoded by any germline gene. The germline-encoded residues and their frequencies in IgG-encoding transcripts are shown at the bottom of the graph.