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. 2017 Nov 13;8:603. doi: 10.3389/fneur.2017.00603

Figure 2.

Figure 2

Four days of resveratrol (RESV) treatment after status epilepticus (SE) restrained the loss of inhibitory interneurons expressing the calcium-binding protein parvalbumin (PV) and the neuropeptide somatostatin (SST) in the dentate gyrus (DG). (A1–C2) and (E1–G2), respectively, illustrate PV+ interneurons and SST+ interneurons in the DG from a naïve control animal (A1–A2, E1–E2), an animal receiving vehicle (VEH) after SE (B1–B2,F1–F2), and an animal receiving RESV after SE (C1–C2,G1–G2). DH, Dentate hilus; GCL, granule cell layer. Scale bar: (A1,B1,C1,E1,F1,G1), 200 µm; (A2,B2,C2,E2,F2,G2), 100 µm. Bar charts display numbers of PV+ (D) and SST+ (H) interneurons in the DG. Animals receiving VEH after SE displayed considerable loss of PV+ and SST+ interneurons. However, animals receiving RESV showed only modest loss of PV+ and SST+ interneuron numbers. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Figure reproduced from Mishra et al. (32).