Table 1.
Characteristics of patients and metastatic sites
| Characteristics | Total (N=1862)
|
Bone metastases
|
p-Value | Brain metastases
|
p-Value | Liver metastases
|
p-Value | Lung metastases
|
p-Value | Distant lymph nodes
|
p-Value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | Yes (%) | No (%) | Yes (%) | No (%) | Yes (%) | No (%) | Yes (%) | No (%) | Yes (%) | No (%) | ||||||
| Age at diagnosis, years | ||||||||||||||||
| Median (range) | 70 (17–98) | 70 (21–97) | 70 (17–98) | <0.001 | 70 (21–96) | 70 (17–98) | 0.113 | 70 (25–98) | 70 (17–97) | 0.402 | 70 (17–98) | 70 (21–98) | 0.047 | 70 (21–97) | 70 (17–98) | 0.001 |
| ≤60 | 444 (23.8) | 217 (48.9) | 227 (51.1) | 20 (4.5) | 424 (95.5) | 105 (23.6) | 339 (76.4) | 165 (37.2) | 279 (62.6) | 182 (41.0) | 262 (59.0) | |||||
| 61–70 | 518 (27.8) | 237 (45.8) | 281 (54.2) | 29 (5.6) | 489 (94.4) | 139 (26.8) | 379 (73.2) | 190 (36.7) | 328 (63.3) | 169 (32.6) | 349 (67.4) | |||||
| 71–80 | 516 (27.7) | 208 (40.3) | 308 (59.7) | 15 (2.9) | 501 (97.1) | 146 (28.3) | 370 (71.7) | 196 (38.0) | 320 (62.0) | 178 (34.5) | 338 (65.5) | |||||
| >80 | 384 (20.6) | 137 (35.7) | 247 (64.3) | 12 (3.1) | 372 (96.9) | 107 (27.9) | 281 (73.2) | 173 (45.1) | 211 (54.9) | 108 (28.1) | 276 (71.9) | |||||
| Year of diagnosis | ||||||||||||||||
| 2010 | 352 (18.9) | 152 (43.2) | 200 (56.8) | 0.370 | 23 (6.5) | 329 (93.5) | 0.090 | 97 (27.6) | 255 (72.4) | 0.375 | 126 (35.8) | 226 (64.2) | 0.411 | 109 (31.0) | 243 (69.0) | 0.324 |
| 2011 | 354 (19.0) | 142 (40.1) | 212 (57.9) | 15 (4.2) | 339 (95.8) | 88 (24.9) | 266 (75.1) | 145 (41.0) | 209 (59.0) | 124 (35.0) | 230 (65.0) | |||||
| 2012 | 387 (20.8) | 182 (47.0) | 205 (53.0) | 11 (2.8) | 376 (97.2) | 106 (27.4) | 281 (72.6) | 162 (41.9) | 225 (58.1) | 123 (31.8) | 264 (68.2) | |||||
| 2013 | 376 (20.2) | 161 (42.8) | 215 (57.2) | 15 (4.0) | 361 (96.0) | 110 (29.3) | 266 (70.7) | 140 (37.2) | 236 (62.8) | 136 (36.2) | 240 (63.8) | |||||
| 2014 | 393 (21.1) | 162 (41.2) | 231 (58.8) | 12 (3.1) | 381 (96.9) | 92 (23.4) | 301 (76.6) | 151 (38.4) | 242 (61.6) | 145 (36.9) | 248 (63.1) | |||||
| Race | ||||||||||||||||
| White | 1589 (85.3) | 680 (42.8) | 909 (57.2) | 0.713 | 67 (4.2) | 1522 (95.8) | 0.552 | 423 (26.6) | 1166 (73.4) | 0.958 | 611 (38.5) | 978 (61.5) | 0.110 | 549 (34.6) | 1040 (65.4) | 0.529 |
| Black | 191 (10.3) | 84 (44.0) | 107 (56.0) | 5 (2.6) | 186 (97.4) | 48 (25.1) | 143 (74.9) | 87 (45.5) | 104 (54.5) | 59 (30.9) | 132 (69.1) | |||||
| Others | 80 (4.3) | 35 (43.8) | 45 (56.2) | 4 (5.0) | 76 (95.0) | 21 (26.3) | 59 (73.7) | 25 (31.3) | 55 (68.7) | 29 (36.3) | 51 (63.7) | |||||
| Unknown | 2 (0.1) | 0 (0) | 2 (100%) | 0 (0) | 2 (100%) | 1 (50.0) | 1 (50.0) | 1 (50.0) | 1 (50.0) | 0 (0) | 2 (100%) | |||||
| Gender | ||||||||||||||||
| Male | 1336 (71.8) | 609 (45.6) | 727 (54.4) | <0.001 | 53 (4.0) | 1283 (96.0) | 0.697 | 366 (27.4) | 970 (72.6) | 0.162 | 498 (37.3) | 838 (62.7) | 0.027 | 460 (34.4) | 876 (65.6) | 0.786 |
| Female | 526 (28.2) | 190 (36.1) | 336 (63.9) | 23 (4.4) | 503 (95.6) | 127 (24.1) | 399 (75.9) | 226 (43.0) | 300 (57.0) | 177 (33.7) | 349 (66.3) | |||||
| Marital status | ||||||||||||||||
| Married | 883 (47.4) | 373 (42.2) | 510 (57.8) | 0.710 | 37 (4.2) | 846 (95.8) | 238 (27.0) | 645 (73.0) | 0.717 | 333 (37.7) | 550 (62.3) | 0.573 | 328 (37.1) | 555 (62.9) | 0.039 | |
| Unmarried | 900 (48.3) | 389 (43.2) | 511 (56.8) | 36 (4.0) | 864 (96.0) | 237 (26.3) | 663 (73.7) | 361 (40.1) | 539 (59.9) | 285 (31.7) | 615 (68.3) | |||||
| Unknown | 79 (4.3) | 37 (46.8) | 42 (53.2) | 3 (3.8) | 76 (96.2) | 18 (22.8) | 61 (77.2) | 30 (38.0) | 49 (62.0) | 24 (30.4) | 55 (69.6) | |||||
| Grade | ||||||||||||||||
| G1 | 17 (0.9) | 6 (35.3) | 11 (64.7) | 0.097 | 0 (0) | 17 (100) | 0.222 | 5 (29.4) | 12 (70.6) | 0.003 | 8 (47.1) | 9 (52.9) | 0.240 | 2 (11.8) | 15 (88.2) | 0.254 |
| G2 | 69 (3.7) | 26 (37.7) | 43 (62.3) | 4 (5.8) | 65 (94.2) | 16 (23.2) | 53 (76.8) | 34 (49.3) | 35 (50.7) | 23 (33.3) | 46 (66.7) | |||||
| G3 | 1379 (74.1) | 576 (41.8) | 803 (58.2) | 50 (3.6) | 1329 (96.4) | 338 (24.5) | 1041 (75.5) | 535 (38.8) | 844 (61.2) | 479 (34.7) | 900 (65.3) | |||||
| Unknown | 397 (21.3) | 191 (48.1) | 206 (51.8) | 22 (5.5) | 375 (94.5) | 134 (33.8) | 263 (66.2) | 147 (37.0) | 250 (63.0) | 133 (33.5) | 264 (66.5) | |||||
| T stage | ||||||||||||||||
| T1 | 309 (16.6) | 124 (40.1) | 185 (59.9) | 0.793 | 10 (3.2) | 299 (96.8) | 0.036 | 84 (27.2) | 225 (72.8) | <0.001 | 125 (40.5) | 184 (59.5) | 0.910 | 104 (33.7) | 205 (66.3) | 0.588 |
| T2 | 765 (41.1) | 331 (43.3) | 434 (56.7) | 30 (4.0) | 735 (96.0) | 172 (22.5) | 593 (77.5) | 297 (38.8) | 468 (61.2) | 249 (32.5) | 516 (67.5) | |||||
| T3 | 158 (8.5) | 67 (42.4) | 91 (57.6) | 5 (3.2) | 153 (96.8) | 38 (24.1) | 120 (75.9) | 60 (38.0) | 98 (62.0) | 53 (33.5) | 105 (66.5) | |||||
| T4 | 327 (17.6) | 140 (42.8) | 187 (57.2) | 9 (2.8) | 318 (97.2) | 83 (25.4) | 244 (74.6) | 121 (37.0) | 206 (63.0) | 122 (37.3) | 205 (62.7) | |||||
| Tx | 303 (16.3) | 137 (45.2) | 166 (54.8) | 22 (7.3) | 281 (92.7) | 116 (38.3) | 187 (61.7) | 121 (39.9) | 182 (60.1) | 109 (36.0) | 194 (64.0) | |||||
| N stage | ||||||||||||||||
| N0 | 955 (51.3) | 437 (45.8) | 518 (54.2) | 0.005 | 44 (4.6) | 911 (95.4) | 0.237 | 263 (27.5) | 692 (72.5) | 0.277 | 399 (41.8) | 556 (58.2) | 0.001 | 204 (21.4) | 751 (78.6) | <0.001 |
| N1 | 197 (10.6) | 73 (37.1) | 124 (62.9) | 6 (3.0) | 191 (97.0) | 54 (27.4) | 143 (72.6) | 76 (38.6) | 121 (61.4) | 87 (44.2) | 110 (55.8) | |||||
| N2 | 353 (19.0) | 135 (38.2) | 218 (61.8) | 8 (2.3) | 345 (97.7) | 84 (23.8) | 269 (76.2) | 118 (33.4) | 235 (66.6) | 199 (56.4) | 154 (43.6) | |||||
| N3 | 124 (6.7) | 43 (34.7) | 81 (65.3) | 5 (4.0) | 119 (96.0) | 25 (20.2) | 99 (79.8) | 32 (25.8) | 92 (74.2) | 86 (69.4) | 38 (30.6) | |||||
| Nx | 233 (12.5) | 111 (47.6) | 122 (52.4) | 13 (5.6) | 220 (94.4) | 67 (28.8) | 166 (71.2) | 99 (42.5) | 134 (57.5) | 61 (26.2) | 172 (73.8) | |||||
| Tumor size, cm | ||||||||||||||||
| ≤2 | 55 (3.0) | 21 (38.2) | 34 (61.8) | 0.010 | 1 (1.8) | 54 (98.2) | 0.584 | 14 (25.5) | 41 (74.5) | 0.600 | 22 (40.0) | 33 (60.0) | <0.001 | 15 (27.3) | 40 (72.7) | 0.324 |
| 2–5 | 404 (21.7) | 161 (39.9) | 243 (60.1) | 17 (4.2) | 387 (95.8) | 114 (28.2) | 290 (71.8) | 157 (38.9) | 247 (61.1) | 147 (36.4) | 257 (63.6) | |||||
| >5 | 430 (23.1) | 160 (37.2) | 264 (61.4) | 14 (3.3) | 416 (96.7) | 104 (24.2) | 326 (75.8) | 203 (47.2) | 227 (52.8) | 136 (31.6) | 294 (68.4) | |||||
| Unknown | 973 (52.3) | 451 (46.4) | 522 (53.6) | 44 (4.5) | 929 (95.5) | 261 (26.8) | 712 (73.2) | 342 (35.1) | 631 (64.9) | 339 (34.8) | 634 (65.2) | |||||
| Radical cystectomy | ||||||||||||||||
| Yes | 124 (6.7) | 38 (30.6) | 86 (69.4) | 0.005 | 3 (2.4) | 121 (97.6) | 0.369 | 15 (12.1) | 109 (87.9) | <0.001 | 40 (32.3) | 84 (67.7) | 0.127 | 54 (43.5) | 70 (56.5) | 0.025 |
| No | 1738 (93.3) | 761 (43.8) | 977 (56.2) | 73 (4.2) | 1665 (95.8) | 478 (27.5) | 1260 (72.5) | 684 (39.4) | 1054 (60.6) | 583 (33.5) | 1155 (66.5) | |||||
| Metastasectomy | ||||||||||||||||
| Yes | 95 (5.1) | 35 (36.8) | 60 (63.2) | 0.242 | 12 (12.6) | 83 (87.4) | <0.001 | 14 (14.7) | 81 (85.3) | 0.008 | 35 (36.8) | 60 (63.2) | 0.746 | 45 (47.4) | 50 (52.6) | 0.007 |
| No | 1767 (94.9) | 764 (43.2) | 1003 (56.8) | 64 (3.6) | 1703 (96.4) | 479 (27.1) | 1288 (72.9) | 689 (39.0) | 1078 (61.0) | 592 (33.5) | 1175 (66.5) | |||||