Table 1.

Results of the top 20 ranked DEGs from Toppgene

Rank	Gene symbol	Gene name	Fold change (SNL versus sham)	Expression	Overall P-value
1	CAV1	Caveolin 1	0.27	Downregulated	4.31E-05
2	CTNNB1	Catenin beta 1	4.41	Upregulated	8.17E-05
3	IRS1	Insulin receptor substrate 1	3.61	Upregulated	9.55E-05
4	NRG1	Neuregulin 1	0.28	Downregulated	1.07E-04
5	STIM1	Stromal interaction molecule 1	0.31	Downregulated	1.37E-04
6	JAK1	Janus kinase 1	0.22	Downregulated	2.61E-04
7	VCL	Vinculin	0.28	Downregulated	3.92E-04
8	CDK6	Cyclin-dependent kinase 6	3.90	Upregulated	4.24E-04
9	IL6ST	Interleukin 6 signal transducer	0.36	Downregulated	4.36E-04
10	SYN1	Synapsin 1	0.24	Downregulated	4.37E-04
11	HTR3B	5-Hydroxytryptamine receptor 3B	0.29	Downregulated	4.53E-04
12	MDM2	MDM2 proto-oncogene	4.31	Upregulated	5.01E-04
13	STXBP1	Syntaxin-binding protein 1	0.20	Downregulated	5.12E-04
14	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2	4.32	Upregulated	5.16E-04
15	SLC17A7	Solute carrier family 17 member 7	0.30	Downregulated	5.91E-04
16	Vamp2	Vesicle-associated membrane protein 2	0.26	Downregulated	6.07E-04
17	TPM1	Tropomyosin 1	0.35	Downregulated	6.09E-04
18	EEF1A2	Eukaryotic translation elongation factor 1 alpha 2	0.38	Downregulated	6.54E-04
19	TFRC	Transferrin receptor	0.28	Downregulated	6.96E-04
20	ATP2A1	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	0.31	Downregulated	4.31E-04

Abbreviations: DEGs, differentially expressed genes; SNL, spinal nerve ligation.