Table 2.
Results of GO annotation enrichment analysis
| Expression | Category | GO term | Count of genes | P-value |
|---|---|---|---|---|
| Upregulated genes | Cluster 1 | |||
| BP | GO:0000122 – negative regulation of transcription from RNA polymerase II promoter | 12 | 1.7E-4 | |
| MF | GO:0043565 – sequence-specific DNA binding | 10 | 6.0E-4 | |
| BP | GO:0045944 – positive regulation of transcription from RNA polymerase II promoter | 13 | 6.8E-4 | |
| BP | GO:0045893 – positive regulation of transcription, DNA templated | 9 | 1.9E-3 | |
| MF | GO:0003682 – chromatin binding | 7 | 1.2E-2 | |
| MF | GO:0003700 – transcription factor activity, sequence-specific DNA binding | 9 | 1.3E-2 | |
| BP | GO:0006355 – regulation of transcription, DNA templated | 10 | 2.4E-2 | |
| BP | GO:0006351 – transcription, DNA templated | 8 | 3.7E-2 | |
| Downregulated genes | Cluster 1 | |||
| CC | GO:0030672 – synaptic vesicle membrane | 7 | 3.4E-6 | |
| CC | GO:0043229 – intracellular organelle | 4 | 1.1E-4 | |
| CC | GO:0008021 – synaptic vesicle | 6 | 2.1E-3 | |
| Cluster 2 | ||||
| MF | GO:0000149 – SNARE binding | 5 | 1.0E-3 | |
| MF | GO:0005484 – SNAP receptor activity | 3 | 3.0E-2 | |
| CC | GO:0031201 – SNARE complex | 3 | 4.7E-2 |
Abbreviations: BP, biological process; CC, cellular component; GO, gene ontology; MF, molecular function; SNAP, soluble N-ethylmaleimide-sensitive factor attachment protein; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptors.