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. 2017 Nov 14;12:8257–8275. doi: 10.2147/IJN.S143776

Figure 3.

Figure 3

Photo-activated PNLs.

Notes: (A) Diagrams of PNLs upon laser irradiation. (B) 1O2 generation by PNLs (DOX: 13.3 μg/mL, HMME: 10 μg/mL) under 532 nm laser (300 mW/cm2) for different irradiation times. (C) TEM images of PNLs without 532 nm laser (300 mW/cm2) irradiation, with 532 nm laser (300 mW/cm2) irradiation for 5 min, with 532 nm laser (300 mW/cm2) irradiation for 10 min and with 532 nm laser (300 mW/cm2) irradiation for 15 min. (D) DOX release from PNLs and NL(DOX), a 532 nm laser (300 mW/cm2, 15 min) was performed at 4 h. (E) HMME release from PNLs and NL(HMME), a 532 nm laser (300 mW/cm2, 15 min) was performed at 4 h. Data presented are mean ± SD (n=6).

Abbreviations: DOX, doxorubicin; HMME, hematoporphyrin monomethyl ether; NL(DOX), DOX-loaded nanoliposome; NL(HMME), HMME-loaded nanoliposome; PNLs, photo-activated nanoliposomes; ROS, reactive oxygen species; TEM, transmission electron microscope.