Table 3.
Volumetric Bone Mineral Density, Size Estimates and Cortical Microarchitecture of the Distal Tibia (Using Standard and Extended Cortical Analyses) in Adolescents and Young Adults with Anorexia Nervosa versus Controls
| Anorexia Nervosa (N=47) |
Controls (N=55) |
p | |
|---|---|---|---|
| Total cross-sectional area (mm2) | 639.4 (589.6–691.9) | 668.9 (574.2–706.5) | 0.22 |
| Cortical perimeter (mm) | 99.2 (95.7–103.0) | 101.6 (94.5–104.5) | 0.17 |
| Endocortical perimeter (mm) | 93.1 (88.6–96.6) | 94.3 (86.6–97.7) | 0.65 |
| Cortical area (mm2) | 101.7 ± 16.3 | 121.4 ± 23.3 | <0.0001# |
| Cortical thickness (mm) | 1.04 ± 0.17 | 1.23 ± 0.24 | <0.0001# |
| Cortical total volume (mm3) | 906.3 ± 128.0 | 1011.6 ± 156.3 | 0.0004# |
| Cortical bone volume (mm3) | 852.3 ± 956.8 | 962.0 ± 149.7 | 0.0001# |
| Cortical porosity (%) | 2.6 (1.8–3.6) | 1.6 (1.0–2.8) | 0.0009# |
| Cortical vBMD (mg HA/cm3) | 868.0 (844.1–887.9) | 882.2 (865.7–911.1) | 0.01# |
| Total vBMD (mg HA/cm3) | 297.5 ± 35.5 | 328.0 ± 52.7 | 0.001# |
Data are reported as mean ± SD or median (interquartile range)
#
Significant after controlling for age and race
All significances held after controlling for multiple comparisons
vBMD: volumetric bone mineral density