Table 4.

Trabecular Microarchitecture at the Tibia (Using Standard Analysis and Individual Trabecula Segmentation) in Adolescents and Young Adults with Anorexia Nervosa and Controls

	Anorexia Nervosa (N=47)	Controls (N=55)	p
	Standard Analysis
Trabecular Area (mm2)	528.1 ± 73.2	532.8 ± 105.1	0.80
Number of trabeculae(1/mm)	1.78 ± 0.23	1.95 ± 0.21	0.0003#
Trabecular thickness (mm)	0.09 ± 0.01	0.08 ± 0.01	0.35
Trabecular separation (mm)	0.48 (0.44–0.52)	0.43 (0.39–0.46)	0.0002#
Inhomogeneity of network (mm)	0.21 (0.19–0.24)	0.19 (0.17–0.21)	0.002#
Trabecular vBMD (mg HA/cm3)	184.3 ± 28.6	196.5 ± 34.5	0.06
	Individual Trabecular Segmentation
Total bone volume fraction (%)	0.29 ± 0.03	0.32 ± 0.04	0.004#
Plate bone volume fraction (%)	0.16 ± 0.05	0.18 ± 0.05	0.12
Rod bone volume fraction (%)	0.13 (0.11–0.14)	0.14 (0.11–0.16)	0.16
Axial bone volume fraction (%)	0.15 ± 0.03	0.16 ± 0.04	0.30
Plate number (1/mm)	1.59 (1.51–1.65)	1.64 (1.55–1.72)	0.03
Rod number (1/mm)	1.68 ± 0.16	1.74 ± 0.16	0.08
Plate trabecular thickness (mm)	0.223 ± 0.010	0.225 ± 0.012	0.42
Rod trabecular thickness (mm)	0.221 (0.217–0.228)	0.216 (0.211–0.221)	0.0002#
Rod-rod junction density(1/mm3)	1.81 (1.42–2.11)	2.07 (1.59–2.65)	0.12
Plate-rod junction density (1/mm3)	3.93 ± 0.72	4.32 ± 0.79	0.004#
Plate-plate junction density (1/mm3)	2.44 ± 0.49	2.68 ± 0.50	0.01#

Data are reported as mean ± SD or median (interquartile range).

^#Significant after controlling for age and race

All significances held after controlling for multiple comparisons

vBMD: volumetric bone mineral density