Table 5.

Predictive performance of Platelet Count, rTEG MA, % ADP INH for postinjury death, massive transfusion and platelets transfusion, adjusted for significant covariates in the subgroups with severe injury (NISS>=25) and with TBI (AIS head/neck >=3)

Outcome=death	NISS>=25				TBI
	AUROC	95% Wald		Comparison with Covariates	AUROC	95% Wald		Comparison with Covariates p-value
		Confidence Limits		p-value		Confidence Limits
% ADP-INH + Covariates	0.8306	0.7532	0.9081	0.5213	0.8746	0.7737	0.9755	0.4098
Platelet Count + Covariates	0.8485	0.7645	0.9326	0.5916	0.8693	0.7637	0.9749	0.8758
rTEG-MA + Covariates	0.8348	0.7585	0.9111	0.9061	0.8746	0.7759	0.9732	0.6582
Covariates only	0.8342	0.7575	0.9109		0.8728	0.7718	0.9738
Outcome=massive transfusion
% ADP-INH +Covariates	0.95	0.9066	0.9934	0.58	NA	NA	NA	NA
Platelet Count +Covariates	0.9541	0.9072	1	0.6284	NA	NA	NA	NA
rTEG-MA +Covariates	0.9453	0.8894	1	0.9709	NA	NA	NA	NA
Covariates only	0.9448	0.8957	0.9939
Outcome=platelet transfusion
% ADP-INH +Covariates	0.8942	0.827	0.9614	0.574	0.8734	0.7888	0.958	0.1655
Platelet Count +Covariates	0.923	0.866	0.98	0.1362	0.8889	0.8006	0.9771	0.1804
rTEG-MA +Covariates	0.9213	0.8649	0.9777	0.1413	0.8597	0.7587	0.9608	0.3455
Covariates only	0.8843	0.8186	0.95		0.8315	0.7335	0.9296

Subgroup analysis of patients with NISS>=25 and those with TBI. In both subgroups, none of the three effects of interest were significantly superior than the model with the covariates in Table 2. Patients with NISS >=25 had significantly higher %ADP-INH than those with NISS<25 [36.5% (19.4–62.9) vs 50.8% (30.4–82.0), p=0.0015]. The %ADP-INH was also higher among TBI patients compared to those without significant TBI, albeit not significantly [38.9% (21.1–68.1) vs 49.6% (27.7–78.4), p=0.17].