Table 3.

PK/PD model parameters for atorvastatin

ADAPT parameter	Value	Corresponding parameter in Narwal et al. [14]
PK component
K 21 (h−1)	3.5	K a
V 1 (L)	3250	V 1
V 3 (L)a	2170	V 2
K 13 (h−1)	0.578	Q/V 1
K 31 (h−1)	0.866	Q/V 3
K 14 (h−1)	0.155	CLpm/V 1
K 41 (h−1)	0.175	CLmp/V m
V 4 (L)	137	V m
K 40 (h−1)	0.847	CLm/V m
PD component
k in (mg/dL·h)	1.14	–b
E max	0.489	–b
EC50 (ng/mL)	22.3	c
k out (mg/dL·h)/(mg/dL)	0.0114	–b

The following model parameters were set to zero: K ₁₀, V ₅, K ₄₅, K ₅₄, and τ

For the ADAPT parameters, single-digit subscripts correspond to the compartment numbers in the models. Two-digit subscripts indicate flux between numbered compartments

CL clearance, EC ₅₀ concentration producing half-maximal inhibition, E _max maximum inhibitory effect, K CL/V, m metabolite, p parent compound, PD pharmacodynamic, PK pharmacokinetic, Q intercompartmental clearance, V volume

^aCalculated as a secondary parameter in ADAPT

^bFrom Kim et al. [13]

^cFrom Dansette et al. [17]