| We performed pharmacokinetic/pharmacodynamic (PK/PD) simulations of the effects on serum low-density lipoprotein cholesterol (LDL-C) levels of various rates of adherence to simvastatin 20 mg and atorvastatin 5 mg. |
| The adherence rate threshold, above which serum levels of LDL-C were maintained in the target range, was > 0.8 for simvastatin and between 0.4 and 0.6 for atorvastatin. |
| We conclude that there is no unique adherence rate threshold, e.g., 0.8, that is universally applicable to all drugs. |
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