FIGURE 4.

The DAI detects response to standard of care (SOC) drugs. CIA-induced rats were treated with vehicle, methotrexate (MTX), etanercept (ENT), or dexamethasone (DEX). For all SOC drugs, the DAI (blue circles) tracked closely with joint size (green squares) (A¹–A⁵) and arthritis scores (orange squares) (B¹–B⁵). Arthritis threshold (dotted gray line) indicates that DAI, ankle joint sizes, and arthritis scores are significantly different from controls, suggesting presence of arthritis (P ≤ 0.05). Error bars are ±SEM. n = 9/group.