Table 3.

Summary statistics for disease course with standard of care (SOC) drugs.

	Vehicle	MTX	ENT	DEX
Digital Arthritis Index (DAI)
Incidence	100% (9 of 9)	89% (8 of 9)	78% (7 of 9)∧	0% (0 of 9)
Onset	13.3 ± 1.7	13.0 ± 1.8	16.1 ± 0.9∗	N/A
Severity	9.7 ± 1.8	9.7 ± 3.3	6.8 ± 2.1∗	2.4 ± 1.1∗
Joint size
Incidence	100% (9 of 9)	89% (8 of 9)	56% (5 of 9)	0% (0 of 9)
Onset	13.0 ± 1.2	13.3 ± 1.4	15.8 ± 1.3∗	N/A
Δ size (in)	0.11 ± 0.03	0.12 ± 0.05	0.05 ± 0.04∗	-0.001 ± 0.006∗
Arthritis score
Incidence	100% (9 of 9)	89% (8 of 9)	22% (2 of 9)	0% (0 of 9)
Onset	13.7 ± 1.6	14.0 ± 1.5	15.0 ± 2.8	N/A
Severity	7.2 ± 1.3	7.1 ± 1.4	3.3 ± 1.7∗	2.0 ± 0∗
Histopathology
Score	7.4 ± 2.8	8.1 ± 3.8	2.6 ± 2.7∗	0.1 ± 0.3∗

Disease incidence, onset, and severity were calculated using the DAI, ankle joint size measurements, and arthritis scores for CIA-induced rats treated with SOC drugs. Values represent means ± std. ^∗P ≤ 0.01 vs. CIA Vehicle-treated group.

^∧The DAI identified two additional ENT-treated rats with arthritis that were not identified via conventional joint measurements. Histopathology scores for the rats were 0.5 and 1.5, indicating very mild disease.