Table 4.
Summary of therapeutic response of nine repurposed compounds by method of arthritis assessment.
| Compound | Total score (histopathology) | Digital Arthritis Index | Inflammation score (histopathology) | Arthritis score | Δ Joint size (in) |
|---|---|---|---|---|---|
| MC-105 | 6.3 ± 4.1** (1) | 7.4 ± 2.0** (1) | 3.02 ± 0.46** (1) | 4.0 ± 2.6 *** (1) | 0.08 ± 0.05* (1) |
| MC-103 | 7.9 ± 4.5 (2) | 7.9 ± 2.5 (2) | 3.67 ± 0.36 (3) | 5.3 ± 3.3 (3) | 0.11 ± 0.06 (3) |
| MC-110 | 8.2 ± 4.1 (3) | 8.3 ± 3.4 (4) | 3.81 ± 0.28 (4) | 5.8 ± 2.6 (4) | 0.11 ± 0.04 (3) |
| MC-114 | 8.4 ± 4.2 (4) | 8.3 ± 2.8 (4) | 3.60 ± 0.52* (2) | 4.3 ± 2.1*** (2) | 0.08 ± 0.04*** (1) |
| MC-104 | 8.9 ± 3.6 (5) | 8.4 ± 2.1 (6) | 4.06 ± 0.37 (5) | 5.8 ± 2.5 (4) | 0.11 ± 0.04 (3) |
| MC-106 | 9.3 ± 2.6 (6) | 9.4 ± 1.6 (8) | 4.25 ± 0.07 (6) | 5.8 ± 1.7 (4)* | 0.11 ± 0.03 (3) |
| MC-101 | 9.8 ± 3.4 (7) | 9.0 ± 2.4 (7) | 4.27 ± 0.42 (7) | 6.3 ± 2.2 (8) | 0.12 ± 0.05 (8) |
| MC-112 | 10.0 ± 2.9 (8) | 9.5 ± 1.4 (9) | 4.50 ± 0.22 (9) | 6.4 ± 1.5 (9) | 0.12 ± 0.04 (8) |
| MC-111 | 10.3 ± 3.9 (9) | 7.9 ± 2.1* (2) | 4.38 ± 0.51 (8) | 6.1 ± 2.4 (7) | 0.11 ± 0.04 (3) |
| Vehicle | 10.8 ± 2.4 | 9.5 ± 1.4 | 4.75 ± 0.07 | 7.1 ± 1.3 | 0.13 ± 0.03 |
Nine repurposed compounds at three doses each are ranked from highest (1) to lowest (9) according to which agent produced the largest to lowest reductions, respectively, based on the assessment method. For the purposes of this table, doses were combined. For each compound, n = 12 and for Vehicle, n = 16. ∗P ≤ 0.05 vs. vehicle, ∗∗P ≤ 0.01 vs. vehicle, ∗∗∗P ≤ 0.001 vs. vehicle.