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. 2017 Nov 14;8:819. doi: 10.3389/fphar.2017.00819

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Copyright © 2017 Chiang, Liang, Liu, Pan, Chen, Yang, Lee, Tsai, Lee and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aliskiren treatment improves cardiac ultrastructure and upregulates the autophagosomes in cardiomyocytes of MI mice by transmission electron microscopy. (A) Cardiomyocytes in the sham-operated mice. (B) The normal cardiomyocyte was shown at higher magnification. (C) The damaged cardiomyocytes in MI mice showed apoptotic bodies (arrow). (D) The damaged cardiomyocyte was shown at higher magnification. (E) Fibroblasts were shown in the infarcted and marginal myocardium at 14D following myocardial infarction. (F) Aliskiren improved the ultrastructure of cardiomyocytes. (G) Accumulation of autophagosomes in cardiomyocytes in aliskiren-treated mice. The arrow denotes the autophagosome. (H) Late autophagosomes contain concentric lamellar inclusions and cytoplasmatic contents (arrow). (I) Heart tissues from aliskiren treatment at MI after 14 days. Bar: 500 nm. Each of the experiments was repeated three times.