Table 1.

Allelic and genotypic associations of SNP rs1136410 with CAD risk.

Model	Alleles (A/G)/Genotypesd		Without adjustment			With adjustmentb
	Cases, N	Controls, N	OR (95%CI)	P	Pempa	OR (95%CI)	Padj
ALLELIC ASSOCIATION ANALYSESc
Discovery set	1500/1032	1462/1130	0.89 (0.80−0.99)	0.040	0.031	0.88 (0.78−0.99)	0.034
Replication set	1897/1177	1800/1288	0.87 (0.78−0.96)	0.006	0.005	0.89 (0.80−0.99)	0.032
Merged set	3397/2209	3262/2418	0.88 (0.81−0.95)	6.29 × 10−4	6.64 × 10−4	0.89 (0.82−0.96)	0.003
GENOTYPIC ASSOCIATION ANALYSESd
Discovery set
Additive	423/654/189	411/640/245	0.89 (0.79−0.99)	0.036	0.038	0.88 (0.78−0.99)	0.031
Recessive	1077/189	1051/245	0.75 (0.61−0.93)	0.007	0.008	0.71 (0.57−0.88)	0.002
Dominant	423/843	411/885	0.93 (0.79−1.09)	0.359	0.533	0.94 (0.79−1.12)	0.473
Replication set
Additive	555/787/195	510/780/254	0.86 (0.77−0.96)	0.005	0.009	0.88 (0.79−0.99)	0.027
Recessive	1342/195	1290/254	0.74 (0.60−0.90)	0.003	0.004	0.76 (0.61−0.93)	0.009
Dominant	555/982	510/1034	0.87 (0.75−1.01)	0.073	0.101	0.91 (0.78−1.06)	0.231
Merged set
Additive	978/1441/384	921/1420/499	0.87 (0.81−0.94)	4.62 × 10−4	2.31 × 10−4	0.88 (0.81−0.96)	0.002
Recessive	2419/384	2341/499	0.75 (0.64−0.86)	6.53 × 10−5	8.32 × 10−5	0.73 (0.63−0.85)	6.45 × 10−5
Dominant	978/1825	921/1919	0.90 (0.80−1.00)	0.051	0.058	0.92 (0.82−1.04)	0.180

^aEmprical P values were obtained from the 100,000-time Monte-Carlo permutation test.

^bAdjusted OR (95%CI) and P_adj values were obtained from logistic regression analyses after adjusting for age, sex, smoking status, alcohol drinking status, BMI, and histories of hyperlipidemia, T2DM, and hypertension.

^cIn allelic association analyses, the major allele A was considered as the reference.

^dIn genotypic association analyses, additive model = AA/AG/GG; recessive model = AG + AA (Reference)/GG.: dominant model = AA (Reference)/GG + AG.

N, number; OR (95%CI), odds ratio: (95% confidence interval).