Table 2.
Subgroup analyses for the association between SNP rs1136410 and CAD risk.
| Variables | SNP rs1136410 (CAD/controls, N) | OR (95%CI)a | Pa | Pinterb | |
|---|---|---|---|---|---|
| AA + AG | GG | ||||
| AGE | |||||
| ≤ 60 | 1197/1039 | 194/236 | 0.69 (0.55–0.86) | 0.001 | 0.733 |
| >60 | 1222/1302 | 190/263 | 0.75 (0.60–0.92) | 0.007 | |
| SEX | |||||
| Male | 1324/1302 | 214/273 | 0.76 (0.62–0.93) | 0.009 | 0.628 |
| Female | 1095/1039 | 170/226 | 0.71 (0.56–0.89) | 0.003 | |
| BMI | |||||
| ≤ 25 | 1259/1472 | 199/309 | 0.69 (0.56–0.85) | 0.001 | 0.934 |
| >25 | 1160/869 | 185/190 | 0.71 (0.55–0.92) | 0.011 | |
| SMOKING STATUS | |||||
| Yes | 807/645 | 154/131 | 0.94 (0.71–1.22) | 0.621 | 0.031 |
| No | 1612/1696 | 230/368 | 0.66 (0.54–0.79) | 9.67 × 10−6 | |
| DRINKING STATUS | |||||
| Yes | 802/573 | 117/134 | 0.61 (0.46–0.81) | 0.001 | 0.150 |
| No | 1617/1768 | 267/365 | 0.79 (0.66–0.94) | 0.010 | |
| HYPERLIPIDEMIA | |||||
| Yes | 682/523 | 147/115 | 0.96 (0.72–1.28) | 0.784 | 0.025 |
| No | 1737/1818 | 237/384 | 0.66 (0.55–0.79) | 6.36 × 10−6 | |
| T2DM | |||||
| Yes | 757/614 | 146/112 | 1.02 (0.76–1.35) | 0.919 | 0.010 |
| No | 1662/1727 | 238/387 | 0.65 (0.54–0.78) | 3.37 × 10−6 | |
| HYPERTENSION | |||||
| Yes | 1432/877 | 227/181 | 0.74 (0.60-0.92) | 0.007 | 0.909 |
| No | 987/1464 | 157/318 | 0.73 (0.59-0.90) | 0.004 | |
a
Adjusted ORs and P values were obtained from logistic regression analyses after adjusting for age, sex, smoking status, alcohol drinking status, BMI, and histories of hyperlipidemia, T2DM, and hypertension.
b
P–value from the multiplicative likelihood ratio test to assess the potential interaction between SNP rs1136410 and selected variables in CAD risk.
Bold values represented statistically significant results, with Pinter < 0.05.
N, number; OR (95%CI), odds ratio (95% confidence interval); CAD, coronary artery disease; BMI, body mass index.