Table 4.

Associations of SNP rs1136410 with lipid levels in both cases and controls.

Lipid (mmol/L)	Controls				CAD
	AA + AG	GG	β (SE)	Pa	AA + AG	GG	β (SE)	Pa
TC
Discovery	5.08 ± 0.97	4.96 ± 0.87	−0.124 (0.067)	0.064	5.23 ± 1.06	5.15 ± 0.83	−0.114 (0.082)	0.163
Replication	5.14 ± 0.98	5.01 ± 0.91	–0.139 (0.065)	0.032	5.24 ± 0.98	5.15 ± 0.90	−0.082 (0.074)	0.271
Merged	5.11 ± 0.98	4.98 ± 0.89	–0.132 (0.047)	0.005	5.24 ± 1.01	5.15 ± 0.86	−0.096 (0.055)	0.081
HDL-c
Discovery	1.21 ± 0.21	1.25 ± 0.23	0.032 (0.015)	0.031	1.00 ± 0.15	1.03 ± 0.14	0.025 (0.012)	0.034
Replication	1.20 ± 0.20	1.24 ± 0.21	0.035 (0.014)	0.012	1.00 ± 0.16	1.03 ± 0.12	0.025 (0.012)	0.033
Merged	1.21 ± 0.20	1.25 ± 0.22	0.034 (0.010)	0.001	1.00 ± 0.15	1.03 ± 0.13	0.026 (0.008)	0.002
LDL-c
Discovery	3.02 ± 0.77	3.02 ± 0.59	0.005 (0.053)	0.917	3.32 ± 0.97	3.26 ± 0.71	−0.084 (0.075)	0.262
Replication	3.03 ± 0.80	3.05 ± 0.77	0.023 (0.055)	0.674	3.24 ± 0.95	3.31 ± 0.69	0.066 (0.071)	0.355
Merged	3.02 ± 0.79	3.04 ± 0.69	0.015 (0.038)	0.702	3.28 ± 0.96	3.28 ± 0.70	−0.002 (0.051)	0.974
TG
Discovery	1.35 ± 0.72	1.34 ± 0.82	−0.014 (0.053)	0.787	1.59 ± 0.84	1.53 ± 0.79	−0.077 (0.066)	0.244
Replication	1.37 ± 0.73	1.36 ± 0.76	−0.003 (0.051)	0.958	1.59 ± 0.84	1.62 ± 0.89	0.029 (0.065)	0.653
Merged	1.36 ± 0.73	1.35 ± 0.79	−0.010 (0.036)	0.774	1.59 ± 0.84	1.58 ± 0.84	−0.017 (0.046)	0.717

^aβ (SE) and P values were obtained from multiple linear regression analyses after adjusting for age, sex, smoking status, alcohol drinking status, BMI, and histories of hyperlipidemia, T2DM, and hypertension.

Bold values represented statistically significant results, with P < 0.05.

TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; TG, triglyceride.