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. 2017 Nov 14;8:816. doi: 10.3389/fphar.2017.00816

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Copyright © 2017 Parikh, Gurev and Rice.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two-dimensional TdP risk map for Dataset 5 (Crumb et al., 2016). The region in green is a low risk region and the region in red is a high risk area. Red dots ( $•$ ) indicate TdP+ drugs and green dots ( $•$ ) indicate TdP− drugs. Blue rectangle outlines the separation of EAD+ (<30% CaV block) and EAD− (> 30% CaV block) regions. The misclassified drugs are (A) Ranolazine (CM3, CP3), Cibenzoline (R5), Mibefradil (R4), Saquinavir (CM2) and Amiodarone (CM1, R1); (B) Cibenzoline, Ranolazine, Mibefradil, Ritonavir (CM3), Saquinavir and Amiodarone; (C) Cibenzoline, Ranolazine, Quinine (CM3), Saquinavir and Amiodarone; and (D) Cibenzoline, Ranolazine, Chlorpromazine (CM1), Saquinavir and Amiodarone. (A,B) TdP Definition 1: TdP+: Drugs belonging to R1,CM1,CH1 category or drug label has TdP warning. (C,D) TdP Definition 2: TdP+: Drugs belonging to CM1 or CM2 category.