Figure 6.

Two-dimensional TdP risk map for Dataset 7 (Li et al., 2017) (A,B), and drugs in Fermini et al. (2016) (C,D). The region in green is a low risk region. Yellow region is an intermediate risk region, and the region in red is a high risk area. Red dots ($•$) indicate high risk drugs, green dots ($•$) indicate low risk drugs and orange dots ($•$) indicate intermediate risk drugs. Metric = % block CaV + % block NaL + degree of drug trapping.