Table 1.

TdP classifiers based on in-vitro ion channel assays.

Feature	In-silico model	Classification		References	NTotal	NCorrect
		TDP+	TDP−
$\frac{I{C}_{50,hERG}}{EFTPC}$	NA	Feature < 30	Feature > 30	Redfern et al., 2003	52	NA
APD90	Ventricular myocyte models of rabbit, rat and human	LDA		Mirams et al., 2011	31	30
$-log(\frac{I{C}_{50,hERG}}{I{C}_{50,CaV}})$	NA	LR		Kramer et al., 2013	55	50
$\frac{1+a_{0}B{P}_{CaV}+a_{1}B{P}_{Na,fast}}{1+a_{2}B{P}_{hERG}}$	NA	LR		Mistry et al., 2015	31 from (Mirams et al., 2011) 55 from (Kramer et al., 2013)	28
TDR	Human ventricular myocyte model	TDR profiles		Christophe, 2015	55 from (Kramer et al., 2013)	NA
$\frac{C_{Drug,Arrhythmia}}{EFTPC}$	3D FEM model of human heart	Feature < 200	Feature > 200	Okada et al., 2015	12	12
EADs	Human ventricular myocyte model	Waveform appearance		Abbasi et al., 2017	12 from (Okada et al., 2015)	11
APD50 & Diastolic Ca2+	Human ventricular myocyte models	SVM and PCA		Lancaster and Sobie, 2016	86 from (Kramer et al., 2013) and (Mirams et al., 2011)	75
$\frac{AUC{I}_{NaL,drug}}{AUC{I}_{NaL,control}}$ $+\frac{AUC{I}_{CaV,drug}}{AUC{I}_{CaV,control}}$	Human ventricular myocyte model	LDA		Li et al., 2017	12	12

LDA, Linear Determinant Analysis; LR, Logistic Regression; SVM, Support Vector Machine; PCA, Principal Component Analysis; C_drug,EAD, concentration of the drug that produces EAD; BP_x, % block of the x (x = Na, fast, CaV, hERG) ion channels; TDR, transmural dispersion of repolarization; C_{drug,Arrhythmia}, concentration of the drug that produces arrhythmia in the model; EAD, early after depolarizations; AUCI_{x,drug/control}, area under the curve of the x (x = CaV, NaL) current transient at steady state action potential in the presence (drug) or absence of the drug (control). Table also lists the number of compounds analyzed in the study (N_Total) and the number of correctly classified compounds (N_correct).