Table 2.

Datasets analyzed for TdP risk. The total number of drugs in each dataset is listed in the “Number compounds” column.

Datasets	Number compounds	Risk categorization tested	Figure/Table
Dataset 1	31	TdP+: R1, R2, R3 categories (RCOD)	Figure 3, Table 4
(Mirams et al., 2011)
Dataset 2	55	TdP+: R1, R2, R3, CM1, CM2, CM3 categories	Figure 3, Table 4
(Kramer et al., 2013)		or label warning (RCOD)
Dataset 3	12	TdP+: R1, R2, R3 categories (RCOD)	Figure 3, Table 4
(Okada et al., 2015)
Dataset 4	86	TdP+: CM1 and CH1 categories,	Figure 3, Table 4
(Lancaster and Sobie, 2016)		Drugs in CM2 and CM3 if label warning (RCOD)
Dataset 5	30	TdP+: R1, R2, R3, CH1, CM1 category	Figures 2A,B, left panel, Figure 4
(Crumb et al., 2016)		or label warning	Tables 4, 5
		TdP+: CM1 and CM2	Figures 2A,B, right panel, Figure 4, Table 5
		TdP+: CM1	Table 5
		TdP+: CM1 and CM3	Table 5
Dataset 6	57	TdP+: CM1	Figure 3, Table 4
(Ando et al., 2017)
Dataset 7	12	TdP+: CP1 and CP2 category	Figure 3, Table 4
(Li et al., 2017)		High: CP1 Intermediate: CP2 Low: CP3 (RCOD)	Figure 6
Dataset 8	197	TdP+ R1, R2, R3, CH1, CM1 category or label warning	Figure 5
(Combined Datasets 1, 2, 3, 5, 6, and 7)		TdP+: CM1 and CM2	Table 6
		TdP+: CM1	Table 6
		TdP+: CM1 and CM3	Table 6
Dataset 9	26	High: CP1 Intermediate: CP2 Low: CP3 (RCOD)	Figure 6
(Fermini et al., 2016)
(IC50,channel extracted from Datasets 1, 2, 3, 5, 6, and 7)

“Risk categorization tested” column refers to the TdP risk definition (see more info on definitions in the text) used to test/train the particular datasets, and the “Figure/Table” column list the corresponding Figure and Table numbers where the results of the particular dataset and risk categorization pair are reported. The IC₅₀ values and risk category of individual drug for each datasets are also reported in the Supplemental Material.