Table 5.

Accuracy scores of TdP classifiers on the direct features for Dataset 5 under four different TdP definitions.

Crumb et al., 2016	Target 1	Target 2	Target 3	Target 4
	2-step Cdrug = IC60,hERG, direct features
Step1:IC60,hERG/EFTPC	73	60	60	60
Step1:IC60,hERG/EFTPC	83	83	70	70
Step2:% block ICaV
Step1:IC60,hERG/EFTPC	80	83	83	76
Step2:% block ICaV & INaL
Step1:IC60,hERG/EFTPC	80	83	83	76
Step2:% block ICaV, INaL & IKs
	2-step Cdrug = IC60,hERG, Derived Features
Step1:IC60,hERG/EFTPC	83	83	83	76
Step2: Derived features

Target1: TdP+ = CM1, CH1, R1, R2, R3, and FDA label QT prolongation and torsade warnings. Target 2: TdP+ = CM1 and CM2. Target 3: TdP+ = CM1. Target 4: TdP+ = CM1 and CM3. Row reporting the maximum accuracies obtained using the derived features is reported for comparision with the direct features.