Skip to main content
. 2017 Nov 14;8:816. doi: 10.3389/fphar.2017.00816

Table 5.

Accuracy scores of TdP classifiers on the direct features for Dataset 5 under four different TdP definitions.

Crumb et al., 2016 Target 1 Target 2 Target 3 Target 4
2-step Cdrug = IC60,hERG, direct features
Step1:IC60,hERG/EFTPC 73 60 60 60
Step1:IC60,hERG/EFTPC 83 83 70 70
Step2:% block ICaV
Step1:IC60,hERG/EFTPC 80 83 83 76
Step2:% block ICaV & INaL
Step1:IC60,hERG/EFTPC 80 83 83 76
Step2:% block ICaV, INaL & IKs
2-step Cdrug = IC60,hERG, Derived Features
Step1:IC60,hERG/EFTPC 83 83 83 76
Step2: Derived features

Target1: TdP+ = CM1, CH1, R1, R2, R3, and FDA label QT prolongation and torsade warnings. Target 2: TdP+ = CM1 and CM2. Target 3: TdP+ = CM1. Target 4: TdP+ = CM1 and CM3. Row reporting the maximum accuracies obtained using the derived features is reported for comparision with the direct features.