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. 2017 Nov 14;8:2238. doi: 10.3389/fmicb.2017.02238

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Copyright © 2017 Malavia, Lehtovirta-Morley, Alamir, Weiß, Gow, Hube and Wilson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pra1 contributes to enlargement and adhesion properties of Goliath cells. (A) PRA1 is expressed in limited zinc medium (LZM). Cells harboring P_PRA1-GFP (Citiulo et al., 2012) or P_ACT1-GFP were analyzed at indicated time points. (B) C. albicans cells were cultured for 2 days in LZM and cell volumes were calculated by V = 4/3 π ab². Data in each column represent at least 30 independent measurements from three independent experiments. pra1Δ cells were significantly smaller than wild type and pra1Δ+PRA1 cells (P < 0.0001, one-way ANOVA). (C) Adherence of indicated C. albicans cells cultured for 2 days in LZM to induce cellular enlargement or for 1 day in LZM + Z to generate yeast cells. Wild type, but not pra1Δ exhibited enhanced adhesion following incubation in LZM (^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗ P < 0.0001).