Table 3.
Non-adherence of prescribers to pharmacotherapeutic measures based on prevailing guidelines
| Usual care period (n = 1435) | Intervention period (n = 1195) | Odds ratios and confidence intervals | ||
|---|---|---|---|---|
| Non-adherence | Non-adherence | OR | 95% CI | |
| 1. Perioperative thrombosis prophylaxis if indicated? | 22/590 (3.7%) | 10/490 (2.0%) | 0.54 | 0.25–1.15 |
| 2. Perioperative bridging of antithrombotics if indicated? | 2/48 (4.2%) | 2/46 (4.3%) | 1.05 | 0.14–7.75 |
| 3. In case of NSAID use, ppi added if indicated? | 5/101 (5.0%) | 3/83 (3.6%) | 0.72 | 0.17–3.11 |
| 4. In case of opioid use, laxative added if indicated? | 154/296 (52%) | 62/190 (32.6%) | 0.45b | 0.31–0.65 |
| 5. In case of impaired renal function (MDRD < 30), no use of NSAID? | 8/50 (16.0%) | 4/40 (10.0%) | 0.54 | 0.15–1.94 |
| 6. In case of radiocontrast, diuretics discontinued? | 16/23 (69.6%) | 20/29 (69.0%) | 0.97 | 0.30–3.18 |
| 7. In case of radiocontrast, NSAID discontinued? | 17/25 (68.0%) | 15/20 (75.0%) | 1.41 | 0.38–5.26 |
| 8. In case of radiocontrast and MDRD < 60, metformin discontinued? | 2/3 (66.7%) | 2/2 (100.0%) | 0.33 | 0.01-12.79 |
| 9. Perioperative antibiotics prophylaxis, if indicated? | 136/832 (16.3%) | 93/661 (14.1%) | 0.84 | 0.63–1.12 |
| 10. Perioperative endocarditis prophylaxis, if indicated? | 6/8 (75%) | 0/3 (0%) | 0.05 | 0.00–1.50 |
| Overall non-adherence | 332/1089 (30.5%) | 193/886 (21.8%) | 0.64b | 0.52–0.78 |
| 0.61a,b | 0.49–0.76 | |||
a OR, adjusted for confounders
b Statistical significant