Table 3.
Adverse drug reactions with an incidence higher than 5% (n = 951)
| All grade | ≥Grade 3 | |||
|---|---|---|---|---|
| n | (%) | N | (%) | |
| Overall | 841 | (88.4) | 665 | (69.9) |
| Hematologic events | ||||
| Neutropenia | 633 | (66.6) | 569 | (59.8) |
| Leukopenia | 593 | (62.4) | 480 | (50.5) |
| Lymphopenia | 175 | (18.4) | 153 | (16.1) |
| Febrile neutropenia | 73 | (7.7) | 73 | (7.7) |
| Anemia | 63 | (6.6) | 35 | (3.7) |
| Non-hematologic events | ||||
| Peripheral neuropathy | 160 | (16.8) | 26 | (2.7) |
| Alopecia | 115 | (12.1) | N/A | |
| Nausea | 107 | (11.3) | 4 | (0.4) |
| Stomatitis | 104 | (10.9) | 16 | (1.7) |
| Pyrexia | 98 | (10.3) | 2 | (0.2) |
| Malaise | 93 | (9.8) | 7 | (0.7) |
| Decreased appetite | 81 | (8.5) | 10 | (1.1) |
| AST increased | 76 | (8.0) | 15 | (1.6) |
| Dysgeusia | 59 | (6.2) | 0 | |
| ALT increased | 52 | (5.5) | 15 | (1.6) |
| C-reactive protein increased | 51 | (5.4) | 6 | (0.6) |
AST aspartate aminotransferase, ALT alanine aminotransferase, N/A not available