Table 1.
Active compounds from sea cucumber
| Compound | Species | Human cell line tested | Ref. |
|---|---|---|---|
| Aqueous extract | Holothuria arenicola | CT26 | [25] |
| Arguside A | Bohadschia argus | HCT-116 | [26] |
| Arguside B, C, D, E | A549, HCT-116, HepG2, MCF-7 | [27] [28] | |
| Bivittoside | Holothuria polii | HCT116, MCF7 | [29] |
| Colochiroside A | Colochirus anceps | p388, HL60, A-549, SpC-A4, MKN28 | [30] |
| Crude saponin | Holothuria leucospilota | B16F10 | [31] |
| Cucumarioside A2–2 | Cucumaria japonica | Ehrlich ascite carcinoma, HL-60 | [32] [33] |
| Ds-echinoside A | Peasonothuria graeffei | Hep G2 | [14] [34] |
| Echinoside A | Holothuria nobilis | 26 human cell line | [35] |
| Echinoside A | Peasonothuria graeffei | Hep G2 | [34] |
| Frondanol A5 | Cucumaria frondosa | HCT116, AsPC-1, S2013 | [36] [37] |
| Frondoside A and B | MDA-MB-23, A549,MDA-MB-435, MCF-7, HepG2, HL-60, AsPC-1, AsPC-1, S2013, AsPC-1 | [38] [13] [39] [33] [40] [41] | |
| Frondoside A | Cucumaria okhotensis | THP-1, HeLa, RT112, RT4, HT-1197 | [42] [43] |
| Griseaside A | Holothuria grisea | HL-60, BEL-7402, Molt-4, A549 | [44] |
| Hillasides A and B | Holothuria hilla Lesson | A549, MCF7, IA9, CAKI-1, PC-3, KB | [45] |
| Holothurin A3 and A4 | Holothuria scabra | KB, Hep-G2 | [23] |
| Okhotoside B1,B2,B3 | Cucumaria okhotensis | HeLa cervical cancer | [42] |
| Organic/water extract | Stichopus chloronotus | C33A, A549 | [46] |
| Pentactasides I,II, III, Philinopsides A and B | Pentacta quadrangularis | P-388, A-549, MCF-7, MKN-28, HCT-116, U87MG | [47] |
| Philinopsides E | P388, HL60, A549, SPC-A4, MKN28 | [24] | |
| Sphingoid bases | Stichopus variegates | Caco-2, DLD-1, WiDr | [21] |
| Sphingoid bases | Sea cucumber | HepG2 | [48] |
| Stichoposide D | Thelenota anax | HL-60, K562 | [49] |
| Violaceusides A and B | Pseudocolochirus violaceus | HL-60, BEL-7402 | [50] |
| Stichorrenoside C and B | Stichopus horrens | Hep-G2, KB, LNCaP, MCF7, SK-Mel2 | [51] |
A431 human epithelial carcinoma cells, A549 non-small lung carcinoma, AsPC-1 pancreatic cancer, BEL-7402 hepatoma, B16F10 melanoma, Caco-2 colon cancer, CAKI-1 renal cancer. CT26 colon carcinoma, C33A cervical cancer, DLD-1 colon adenocarcinoma, HCT-8 colorectal adenocarcinoma, HCT116 colon cancer, HeLa cervical cancer, Hep G2 hepatocellular liver carcinoma, Hep3B hepatoma, HL-60 leukemia, HO8901 ovarian carcinoma, HT-1197 urothelial carcinoma, IA9 ovarian ca, KB epidermoid cancer, KB-VIN vincristine-resistant, K562 leukemia, LNCaP prostate cancer, LNM35 lung cancer, MCF7 breast adenocarcinoma, and MDA-MB-231 Luc-2 breast cancer, MDA-MB-435 breast cancer, MKN-28 gastric cancer, Molt-4 leukemia, NCI-H460-Luc2 lung cancer, PC-3 prostate cancer, p388 leukemia, RT4 urothelial carcinoma, RT112 urothelial carcinoma, TCCSUP urothelial carcinoma, THP-1 leukemia, T-24 urothelial carcinoma, SGC-7901 gastric cancer, SK-Mel2 melanoma, SPC-A4 lung adenocarcinoma, S2013 pancreatic cancer, U87MG glioblastoma, WiDr colon carcinoma, W138 human fetal lung fibroblast, 486p urothelial carcinoma