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. 2017 Nov 14;7:469. doi: 10.3389/fcimb.2017.00469

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Copyright © 2017 Boesze-Battaglia, Walker, Dhingra, Kandror, Tang and Shenker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the effects of Cdt on PI-3K signaling blockade in Jurkat^WT vs. Jurkat^Cg− cells. Jurkat^WT and Jurkat^Cg− cells were treated with 0–25 pg/ml Cdt for 2 h and then analyzed by Western blot for pAkt (S473), Akt, pGSK3β (S9), GSK3β, and GAPDH as a loading control. (A) Contains a representative Western blot showing the effect of Cdt on Akt and GSK3β phosphorylation. (B) Shows the results of Western blot analyses from three experiments; blots were analyzed by digital densitometry and are expressed as a percentage of the relative intensity of untreated control cells; mean ± S.E.M. for three experiments are plotted. ^*Indicates statistical significance (p < 0.05) when compared to untreated control cells.