Figure 6.

Time course of internalization of Kir2.1 and Nav1.5 channels. (A–D) Mean normalized density of the currents recorded in CHO cells expressing the constructs indicated and incubated with BFA (50 ng/mL) (solid circles) for 0 (Control), 3, 6, 18, and 24 h or with 1% ethanol (open circles) for 0, 6, and 24 h. Half-time constants (τ) yielded by the monoexponential fit to the BFA data are also shown. Each point represents the mean ± SEM of (n) cells of ≥4 preparations.