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. 2017 Nov 14;8:903. doi: 10.3389/fphys.2017.00903

Figure 7.

Figure 7

Effects of the dynamin-2 inhibition on Kir2.1 and Nav1.5 channels internalization. (A) Schematic representation of a cell highlighting the role of dynamin-2 in ion channel endocytosis. (B,C) IKir2.1 (B) and INav1.5 (C) traces recorded by applying the protocols shown at the top in CHO cells transfected with the constructs indicated. The dashed lines represent the zero current level. (D,E) Bar graphs depicting IKir2.1 density at −120 mV (D) and peak INav1.5 (E) in cells expressing Kir2.1 and Nav1.5 channels, respectively in the absence or presence of the constructs indicated cotransfected or not with p.K44A dynamin-2. Each bar represents the mean ± SEM of “n” experiments of ≥3 preparations. *P < 0.01 vs. cells transfected with Kir2.1 or Nav1.5 channels alone. For clarity the results of other statistical comparisons were not shown.