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. 2017 Nov 14;8:903. doi: 10.3389/fphys.2017.00903

Figure 8.

Figure 8

Kir2.1 and Nav1.5 channel complexes are ubyquitinated and degraded by the proteasome. (A,B) IKir2.1 density at −120 mV (A) and peak INav1.5 (B) recorded in cells expressing Kir2.1 and Nav1.5 channels cotransfected or not with the ubiquitin ligase Nedd4-2. (C,D) IKir2.1 density at −120 mV (C) and peak INav1.5 (D) recorded in cells expressing Kir2.1 and Nav1.5 channels incubated or not with the proteasome inhibitor MG132 (2 μM for 2 h). Each bar represents the mean ± SEM of “n” experiments of ≥4 preparations. *P < 0.05 vs. cells transfected with Kir2.1 or Nav1.5 channels alone; #P < 0.05 vs. cells transfected with Kir2.1+Nav1.5. For clarity the results of other statistical comparisons were not shown.