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. 2017 Nov 14;8:822. doi: 10.3389/fphar.2017.00822

Figure 2.

Figure 2

CaMKII inhibition impairs the maintenance of CTA-LTM. (A) Schematic representation of the experimental procedure. (B) Schematic representation and representative micrographs showing cannulae placement. IC, insular cortex. Scale bar: 1 mm. (C) Saccharin consumption during acquisition, short-term memory aversion test (STM) and long-term memory aversion test (LTM) for CTA+STM+ACSF, CTA+STM+CaMKIINtide, CTA+CaMKIINtide and pCTA+STM+CaMKIINtide groups. Note that local infusion of myr-CaMKIINtide in the IC 24 h after acquisition, either in the presence or absence of STM-test produced a severe deficit during the LTM aversion test. **p < 0.001. Arrow indicates microinfusion.