Table 2.

Effects of pharmacotherapies for mood disorders on locomotor and SCN rhythms.

Drug	Effects on locomotor activity in rodents	Effects on the SCN in rodents
SSRIs	Phase-advanced locomotor activity [130, 131] Shortened locomotor activity period [141, 142]	Phase-advanced neural activity when applied with L-tryptophan in rats [56] Phase-advanced neural activity [137] Shortened PER1::LUC period [143]
Lithium	Lengthened locomotor activity period [153–155]	Lengthened neural activity period [158] Lengthened PER2::LUC period [153, 156, 159, 160] Increased amplitude of PER2::LUC rhythms [153, 156]
Valproic acid	Shortened locomotor activity period [183]	Phase-shifted PER2::LUC rhythms [160] Increased amplitude of PER2::LUC rhythms [160] Shortened PER2::LUC period [183]
Agomelatine	Phase-advanced rhythms [227] Accelerated re-entrainment [232] Entrained locomotor activity rhythms [228, 233]	Decreased firing rate [230, 231]