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Weight gain of treated and untreated rats during treatment. Shigella flexneri diarrheic rats were treated for 5 days with 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg of ethanolic extract of D. multiflora or ciprofloxacin. Data are the mean ± SEM (n = 6). Significant difference: ∗p < 0.05 compared with negative control rats; ap < 0.05 compared with positive control; day 0: S. flexneri administration; day 1: diarrhea appearance and treatment start.
