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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Eur J Med Chem. 2017 Oct 10;141:596–602. doi: 10.1016/j.ejmech.2017.10.022

Scheme 1.

Scheme 1

Reagents and conditions: a) Et3N, EtOH, microwave, 100°C, 48–82%; b) morpholine, xantphos, Pd(dba)2, Cs2CO3, toluene, 65°C, 30–49%; c) LiOH, H2O/THF, 93–97%; d) (COCl)2, DMF, DCM, then NH2OH.HCl, Et3N, H2O/THF, 21–24%.