Table 2.
Hazard Ratios and 95% CIs for the Association Between Sitting Time, Total Physical Activity, and Risk of Colorectal, Rectal, and Colon Cancer
| Sitting Time (hrs/day) | Physical Activity (MET-hrs/week) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| ≤ 5 | 5.1–9.9 | ≥ 10 | p trend | Inactive (≤1.7) | Low (1.8–7.4) | Medium (7.5–20) | High (>20) | p trend | |
| Colorectal | |||||||||
| Cases | 365 | 516 | 264 | 249 | 430 | 282 | 184 | ||
| Person-yrs | 336,659 | 410,944 | 252,054 | 171,432 | 350,331 | 212,285 | 265,607 | ||
| Age-adjusted | 1.00 | 1.11 (0.97–1.28) | 1.22 (1.01–1.47) | 0.04 | 1.00 | 0.88 (0.73–1.06) | 0.81 (0.68–0.96) | 0.69 (0.57–0.84) | <0.001 |
| MV-adjusted | 1.00 | 1.11 (0.97–1.28) | 1.15 (0.95–1.40) | 0.16 | 1.00 | 0.94 (0.78–1.14) | 0.92 (0.77–1.10) | 0.81 (0.66–1.00) | 0.04 |
| MV + BMI & DM | 1.00 | 1.10 (0.95–1.26) | 1.12 (0.92–1.35) | 0.29 | 1.00 | 0.96 (0.80–1.16) | 0.96 (0.80–1.15) | 0.87 (0.71–1.07) | 0.15 |
| Rectal | |||||||||
| Cases | 62 | 93 | 47 | 29 | 78 | 57 | 38 | ||
| Age-adjusted | 1.00 | 1.13 (0.81–1.57) | 1.11 (0.71–1.73) | 0.67 | 1.00 | 0.90 (0.59–1.37) | 0.80 (0.54–1.18) | 0.39 (0.24–0.65) | <0.0001 |
| MV-adjusted | 1.00 | 1.10 (0.79–1.53) | 0.97 (0.61–1.53) | 0.85 | 1.00 | 0.95 (0.62–1.45) | 0.87 (0.58–1.32) | 0.44 (0.26–0.74) | <0.001 |
| MV + BMI & DM | 1.00 | 1.08 (0.78–1.51) | 0.94 (0.59–1.48) | 0.74 | 1.00 | 0.97 (0.64–1.49) | 0.92 (0.61–1.39) | 0.47 (0.28–0.80) | 0.001 |
| Colon | |||||||||
| Cases | 311 | 432 | 221 | 221 | 357 | 235 | 151 | ||
| Age-adjusted | 1.00 | 1.11 (0.96–1.29) | 1.23 (1.00–1.50) | 0.05 | 1.00 | 0.89 (0.73–1.10) | 0.81 (0.67–0.98) | 0.75 (0.61–0.92) | <0.01 |
| MV-adjusted | 1.00 | 1.12 (0.96–1.30) | 1.17 (0.95–1.45) | 0.14 | 1.00 | 0.96 (0.78–1.18) | 0.92 (0.75–1.12) | 0.89 (0.71–1.11) | 0.31 |
| MV + BMI & DM | 1.00 | 1.10 (0.95–1.28) | 1.14 (0.92–1.40) | 0.25 | 1.00 | 0.99 (0.80–1.21) | 0.96 (0.79–1.18) | 0.95 (0.76–1.19) | 0.65 |
MV model: Race, education, total caloric intake, fiber intake, calcium intake, vitamin D intake, red meat intake, alcohol, hormone replacement therapy, income, marital status, smoking, family history of CRC, CRC screening, aspirin, multivitamin use, physical activity (ST model), and sitting time (PA model)