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A cyclical pathway for PP-InsP turnover. Current evidence (described in the text) indicates that the pathway for PP-InsP turnover may be described as a cyclical interconversion of InsP6, 5-InsP7, 1,5-InsP8, and 1-InsP7, upon which is superimposed “futile” cycling between 5-InsP7 and 1,5-InsP8 (see text for details). IP6K, inositol hexakisphosphate kinase; PPIP5K, diphosphoinositolpentakisphosphate kinase; DIPP, diphosphoinositol polyphosphate phosphatase
