Table 1.
Reference | Publication date | First and last author | Journal | Tumor type | Patients | Peptides tested | T cell responses | Test method | Peptide lengths |
---|---|---|---|---|---|---|---|---|---|
(16) | 2013–05 | Robbins et al. and Rosenberg | Nat Med | SKCM | 3 | 227 | 10 | ELISPOT | 9–10 |
(17) | 2013–11 | Van Roij et al. and Schumacher | J Clin Oncol | SKCM | 1 | – | 1 | FLT | 9 |
(18) | 2014–03 | Wick et al. and Nelson | Clin Cancer Res | HGSC | 3 | 109 | 1 | ELISPOT | 8–11 |
(19) | 2014–06 | Rajasagi et al. and Wu | Blood | CLL | 2 | 48 | 3 | ELISPOT | 9–10 |
(20) | 2014–07 | Lu et al. and Robbins | Clin Cancer Res | SKCM | 2 | 10 | 2 | ELISA | 8–11 |
(1) | 2014–12 | Snyder et al. and Chan | N Engl J Med | SKCM | 1 | – | 1 | ICS | 9 |
(2) | 2015–04 | Rizvi et al. and Chan | Science | NSCLC | 1 | – | 1 | FLT | 9 |
(21) | 2015–10 | Cohen et al. Robbins | J Clin Invest | SKCM | 8 | 427 | 9 | FLT | 9–10 |
(22) | 2016–01 | Kalaora et al. and Samuels | Oncotarget | SKCM | 1 | 2 | 1 | ICS | 9, 11 |
(23) | 2016–03 | McGranahan et al. and Swanton | Science | NSCLC | 2a | 642a | 3/8a | FLT/BLM | 9–11 |
(24) | 2016–05 | Strønen et al. and Schumacher | Science | SKCM | 4 | 56 | 11 | FLT | 9–11 |
(25) | 2016–05 | Bassani-Sternberg et al. and Krackhardt | Nature Commun | SKCM | 1 | 8 | 2 | MS-FLT | 8–10, 12 |
(26) | 2016–08 | Bentzen et al. and Hadrup | Nat Biotechnol | NSCLC | 2a | 703a | 9a | BLM | 9–11 |
Total | 13 | 4 | 30 | 1,874 | 53 | 5 | 5 |
1,874 unique tested peptides, 1,948 peptide-HLA combinations, from 27 HLA alleles.
FLT, fluorescently labeled tetramers; BLM, DNA barcode-labeled multimers; ICS, intracellular cytokine staining; MS, mass spectrometry; SKCM, skin cutaneous melanoma; NSCLC, non-small cell lung cancer; CLL, chronic lymphocytic leukemia; HGSC, ovarian high grade serous carcinoma.
aPeptides and patient overlap between studies.